Novel Neurobioink
Our novel neurobioink is a fibrin-based bioink which supports multiple different cell lines such as human induced pluripotent stem cells (HiPSCs), neural progenitor cells (NPCs), and mesenchymal stem cells (MSCs). It can be used on various bioprinting systems such as Aspect Biosystems, Allevi, and CELLINK.
Our novel neurobioink is a research-grade bioink, which generates stable and reproducible 3D-structures (constructs) that can remain in culture for over a month. Not only does neurobioink allow for long-term culture but it also allows cells to maintain high viability and promotes neuronal differentiation. It is less labor-intensive and requires fewer production steps.
Publications
- Abelseth E, Abelseth L, De la Vega L, Beyer ST, Wadsworth SJ, Willerth SM.
3D printing of neural tissues derived from human induced pluripotent stem cells using a fibrin-based bioink.
ACS Biomaterials Science and Engineering. 2018;5(1):234-43. - Lee, C., Abelseth, E., de la Vega, L., and Willerth, S.M.
Bioprinting a novel glioblastoma tumor model using a fibrin based bioink for drug screening.
Materials Today Chemistry. 2019, (12). 78-84. - De la Vega, L., Rosas Gomez, D., Abelseth, E., Abelseth, L., Alisson da Silva, V. and Willerth, S.M.
3D bioprinting human induced pluripotent stem cell-derived neural tissues using a novel Lab-on-a-Printer technology.
Applied Science. 2018. 2018, 8(2414). 1-13. - Sharma, R., Smits, I.P.M, De La Vega, L., Lee, C. and Willerth, S.M.
3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres
Frontiers in Bioengineering and Biotechnology. 2020, 8(57). - Smits, I.P.M, Blaschuk, O.W.,Willerth, S.M.
Novel N-cadherin antagonist causes glioblastoma cell death in a #D bioprinted co-culture model
Biochemical and Biophysical Research Communications. 2020. 2020, 527(2),162-168.