Novel Bioink
Our novel neurobioink is a fibrin-based bioink which supports multiple different cell lines such as human induced pluripotent stem cells (HiPSCs), neural progenitor cells (NPCs), and mesenchymal stem cells (MSCs). We are currently forumlating a bioink for extrsuion-based bioprinters, and are working with the Allevi, and CELLINK bioprinters.
Our novel neurobioink is a research-grade bioink, which generates stable and reproducible 3D-structures (constructs) that can remain in culture for over a month. Not only does neurobioink allow for long-term culture but it also allows cells to maintain high viability and promotes neuronal differentiation. It is less labor-intensive and requires fewer production steps.
Check out our publications on the Aspect Biosystems RX1 Bioprinter!
- Abelseth E, Abelseth L, De la Vega L, Beyer ST, Wadsworth SJ, Willerth SM.
3D printing of neural tissues derived from human induced pluripotent stem cells using a fibrin-based bioink.
ACS Biomaterials Science and Engineering. 2018;5(1):234-43. - Lee, C., Abelseth, E., de la Vega, L., and Willerth, S.M.
Bioprinting a novel glioblastoma tumor model using a fibrin based bioink for drug screening.
Materials Today Chemistry. 2019, (12). 78-84. - De la Vega, L., Rosas Gomez, D., Abelseth, E., Abelseth, L., Alisson da Silva, V. and Willerth, S.M.
3D bioprinting human induced pluripotent stem cell-derived neural tissues using a novel Lab-on-a-Printer technology.
Applied Science. 2018. 2018, 8(2414). 1-13. - Sharma, R., Smits, I.P.M, De La Vega, L., Lee, C. and Willerth, S.M.
3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres
Frontiers in Bioengineering and Biotechnology. 2020, 8(57). - Smits, I.P.M, Blaschuk, O.W.,Willerth, S.M.
Novel N-cadherin antagonist causes glioblastoma cell death in a #D bioprinted co-culture model
Biochemical and Biophysical Research Communications. 2020. 2020, 527(2),162-168.