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AxolotlBiosciences

Novel Bioink

Our novel neurobioink is a fibrin-based bioink which supports multiple different cell lines such as human induced pluripotent stem cells (HiPSCs), neural progenitor cells (NPCs), and mesenchymal stem cells (MSCs). We are currently forumlating a bioink for extrusion-based bioprinters, and are working with the Allevi, and CELLINK bioprinters.

 

 

Our novel neurobioink is a research-grade bioink, which generates stable and reproducible 3D-structures (constructs) that can remain in culture for over a month. Not only does neurobioink allow for long-term culture but it also allows cells to maintain high viability and promotes neuronal differentiation. It is less labor-intensive and requires fewer production steps.

 

Check out our publications on the Aspect Biosystems RX1 Bioprinter!

 

 

 

Publications
  • Abelseth E, Abelseth L, De la Vega L, Beyer ST, Wadsworth SJ, Willerth SM.
    3D printing of neural tissues derived from human induced pluripotent stem cells using a fibrin-based bioink.
    ACS Biomaterials Science and Engineering. 2018;5(1):234-43.
  • Lee, C., Abelseth, E., de la Vega, L., and Willerth, S.M.
    Bioprinting a novel glioblastoma tumor model using a fibrin based bioink for drug screening.
    Materials Today Chemistry. 2019, (12). 78-84.
  • De la Vega, L., Rosas Gomez, D., Abelseth, E., Abelseth, L., Alisson da Silva, V. and Willerth, S.M.
    3D bioprinting human induced pluripotent stem cell-derived neural tissues using a novel Lab-on-a-Printer technology.
    Applied Science. 2018. 2018, 8(2414). 1-13.
  • Sharma, R., Smits, I.P.M, De La Vega, L., Lee, C. and Willerth, S.M.
    3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres 

    Frontiers in Bioengineering and Biotechnology. 2020, 8(57).
  • Smits, I.P.M, Blaschuk, O.W.,Willerth, S.M.
    Novel N-cadherin antagonist causes glioblastoma cell death in a #D bioprinted co-culture model

    Biochemical and Biophysical Research Communications. 2020. 2020, 527(2),162-168.
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